Fresh analysis suggests that individuals who discontinue blockbuster GLP-1 drugs like Mounjaro or Wegovy can put back on lost weight far faster than those who end conventional diet and exercise plans.
Published data in a major health publication shows that while overweight people often shed a large proportion of their body weight while undergoing treatment, the mass comes back at an estimated rate of 0.8 kg per month once they quit.
"Individuals buying such drugs need to be informed of the danger of rapid weight regain when the medication concludes," stated lead investigator Dr. Susan Jebb.
That rate of regain means a return to starting mass within about 18 months.
Analyzing Approaches
The study, which examined 37 of studies involving over 9,000 of participants, contrasted the outcomes of the injectable medications with older methods.
Researchers point out that people who shed pounds through diet and exercise typically see a slower creep back—perhaps 0.1 kg a month—once they finish.
Explaining the Rapid Rebound
Doctors believe the mode of action of the jabs accounts for the amplified regain.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which helps regulate appetite.
"Long-term administration of the hormone concentrations far above than normal could lead to the system to produce less of its endogenous GLP-1, and may also diminish sensitivity to its effects," explained Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication results in appetite is uncontrolled, making excessive eating a significant risk."
A Chronic Issue?
Health authorities recommend the jabs for individuals with obesity-related health risks, accompanied by recommended diet and exercise modifications.
A number of clinicians contend that, considering the high risk of relapse, the therapy might need to be ongoing.
This perspective is supported by drug manufacturers, who state that the findings "highlight the long-term character of obesity," akin to managing conditions like high blood pressure.
User Experiences
Individuals who have come off the jabs report a sudden resurgence of cravings.
"It was like a trigger flipping and I was suddenly extremely hungry," described one woman.
This difficulty is compounded if users have not developed sustainable dietary or behavioural modifications during treatment.
Significant Interest
Figures indicate that millions of people in the UK have used these injections in the past year, with demand continuing to grow.
- Use is greater among women compared to men.
- The middle-aged demographic shows the greatest usage rates.
- A large proportion obtain the medications through private healthcare rather than the NHS.
In conclusion, experts stress that while the jabs are powerful tools for weight loss, they are not a standalone fix and maintained weight loss likely depends on combined lifestyle support.
